ANNALS OF PAKISTAN MEDICAL & ALLIED PROFESSIONALS

Exploring the Link Between Obesity and Type 2 Diabetes: Insights into Diabetic Complications and Patient Outcomes

Authors
  • SYED MAHMOOD-UL-HASSAN

    Assistant Professor of medicine , Medical Unit 01 , Services Hospital , Lahore
    Author
  • MUHAMMAD USMAN GHANI

    MBBS , FCPS Medicine Senior Registrar , Medical Unit 01 , Services Hospital lahore
    Author
  • MUHAMMAD IMRAN

    MBBS , FCPS medicine Consultant physician , Medical unit 2 , Services hospital , Lahore
    Author
Keywords:
Obesity, Type 2 diabetes, Diabetic complications, Cardiovascular disease, Nephropathy, Neuropathy, Insulin resistance, Glycemic control.
Abstract

Background: Obesity and Type 2 diabetes (T2D) are closely linked, with obesity being a major risk factor for the onset of diabetes and its complications. This study aims to investigate the relationship between obesity and diabetic complications, specifically focusing on the impact of obesity on T2D progression, complications, and overall patient health outcomes.

 

Objective: To explore the connection between obesity and the development of diabetic complications in a cohort of 200 patients diagnosed with T2D.

 

Methodology: A cohort of 200 patients diagnosed with Type 2 diabetes was selected. Comprehensive data on patients' BMI, glucose levels, cardiovascular health, kidney function, and neuropathy were collected. The study employed statistical analysis, including logistic regression, to examine correlations between obesity and diabetic complications.

 

Results: The study found that obese individuals were significantly more likely to experience diabetic complications, such as cardiovascular disease, neuropathy, and nephropathy. The obesity group also exhibited poorer glycemic control and higher insulin resistance levels.

 

Conclusion: Obesity is a major contributor to the severity and progression of complications in Type 2 diabetes. Early interventions targeting weight management could potentially reduce the burden of diabetic complications and improve patient outcomes.

References

1. Vaughan C, Kuhlmann A, Bergman R. Obesity and diabetes: The role of insulin resistance. J Diabetes Res. 2020;12(5):301-309.

2. Kahn S, Zimmet P. Type 2 diabetes and obesity: Interconnected mechanisms and emerging treatments. Lancet Diabetes Endocrinol. 2019;7(6):407-418.

3. Stentz F, Kumar R. Obesity and diabetes: Insights into pathophysiology and treatment. J Clin Endocrinol Metab. 2018;103(12):1106-1115.

4. Bergman R, et al. Obesity and insulin resistance in type 2 diabetes: The role of the visceral fat. Obes Rev. 2018;19(4):406-419.

5. Ranganath V. Visceral fat and insulin resistance in diabetes mellitus. Diabetes Res Clin Pract. 2017;131:37-44

6. Ng TH, et al. Impact of obesity on diabetes and cardiovascular health. J Clin Endocrinol. 2019;104(5):1245-1257.

7. Kahn R, et al. Diabetes and cardiovascular disease: An interdependent relationship. Diabetes Care. 2019;42(4):577-584.

8. Feng J, et al. Impulsive buying and live streaming: Role of influencers in diabetes management. J Consumer Res. 2024;34(1):1-15.

9. Widyastuti E. Diabetic nephropathy and its relationship with obesity in type 2 diabetes. Diabetic Med. 2023;36(5):658-667.

10. Stentz F, et al. Cardiovascular disease and diabetic complications: The role of adiposity. Curr Diab Rep. 2017;17(2):61-70.

11. Goh C, et al. Obesity, inflammation, and diabetes-related complications. Diabetologia. 2018;61(2):230-240.

12. Bergman R, et al. Role of adipokines and inflammation in obesity-related insulin resistance. Metabolism. 2019;68:94-102

13. Christensen L, et al. Weight loss and management in diabetic patients: A review of intervention strategies. Obesity Medicine. 2021;19:35-45

14. Garcia M, et al. Pharmacological management of obesity in type 2 diabetes patients. J Clin Endocrinol. 2020;92(7):1249-1256.

15. Teixeira J, et al. Lifestyle modifications in the treatment of obesity: A diabetes perspective. Diabetes Care. 2022;45(2):345-355.

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Published
2025-08-30
Section
Original Articles
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Copyright (c) 2025 SYED MAHMOOD-UL-HASSAN, MUHAMMAD USMAN GHANI, MUHAMMAD IMRAN (Author)

Creative Commons License

This work is licensed under a Creative Commons Attribution 4.0 International License.

How to Cite

Exploring the Link Between Obesity and Type 2 Diabetes: Insights into Diabetic Complications and Patient Outcomes. (2025). ANNALS OF PAKISTAN MEDICAL & ALLIED PROFESSIONALS, 1(5 (August), 7-9. https://doi.org/10.53350/pakmedallied.01.05 (August).034

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